부산대학교 도서관

To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1601-0825.2009.01572.x Byline: Y Fujinami (1), P-L Wang (1,2), T Fukui (2), K Nakano (3), T Ara (1,2), Y Fujigaki (4), Y Imamura (1,2), T Hattori (1,2), S Yanagisawa (4), T Kawakami (3) Keywords: passive smoking; cigarette smoke; saliva; amylase; peroxidase Abstract: Objective: Passive smoking is the involuntary inhalation of cigarette smoke (CS) and has an adverse impact on oral health. We examined the effect of CS exposure on saliva and salivary glands (SGs). Methods: Cigarette smoke-exposed rats were intermittently housed in an animal chamber with whole-body exposure to CS until killed. Whole saliva was collected before CS exposure (0 day), and 15 and 30 days after the start of CS exposure. Saliva secretion was stimulated by administration of isoproterenol and pilocarpine after anesthesia. SGs were collected on 31 days. Results: The increase in body weight of the CS-exposed rats was less than that of the control rats. Salivary flow rates did not differ at 0, 15 or 30 days after the start of CS exposure. However, the amylase and peroxidase activities and total protein content in the saliva were significantly lower in 15-day CS-exposed rats than in 15-day control rats. Histological examination of the SGs of CS-exposed rats showed vacuolar degeneration, vasodilation and hyperemia. Conclusion: These results suggest that CS exposure has adverse impacts on salivary composition and SGs, which could aggravate the oral environment. Author Affiliation: (1)Department of Pharmacology (2)Department of Hard Tissue Research, Graduate School of Oral Medicine (3)Hard Tissue Pathology Unit, Graduate School of Oral Medicine (4)Department of Oral Health, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan Article History: Received 18 October 2008; revised 8 April 2009; accepted 8 April 2009 Article note: Pao-Li Wang, DDS, PhD, Department of Pharmacology, School of Oral Medicine, Matsumoto Dental University, 1780 Gobara, Hirooka, Shiojiri, Nagano 399-0781, Japan. Tel: +81-263-51-2102, Fax: +81-263-51-2102, E-mail: ohhourei@po.mdu.ac.jp