학술논문
Delayed neuronal death in ischemic hippocampus involves stimulation of protein tyrosine phosphorylation
Cell Physiology
Cell Physiology
Document Type
Academic Journal
Author
Source
American Journal of Physiology (Consolidated). Oct 1996, Vol. 271 Issue 4, pC1085, 13 p.
Subject
Language
ISSN
0002-9513
Abstract
Tyrosine kinase acts as a messenger of neuronal cell death during the selective degeneration of hippocampal pyramid cells in transient forebrain ischemia models. Protein tyrosine phosphorylation of pp42 was detected after the nonlethal and lethal ischemia of the hippocampus and cerebral cortex. The ischemic hippocampal CA1 neurons also exhibited increased expression of phosphotyrosyl proteins indicating the anti-microtubule-associated protein kinase activity of pp42.