학술논문
Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway
Document Type
Academic Journal
Source
Proceedings of the National Academy of Sciences of the United States. August 29, 1995, Vol. 92 Issue 18, p8318, 5 p.
Subject
Language
ISSN
0027-8424
Abstract
The activation of the interleukin 1-beta (IL-1-beta)-converting enzyme (ICE) family may be an important factor in tumor necrosis factor cytotoxicity. The cowpox virus crmA protein restrains the enzymatic activity of ICE and ICE-mediated apoptosis. HeLa cells overexpressing crmA resists apoptosis induced by ICE but not by Ich-1. HeLa cells are also resistant to TNF-alpha/cycloheximide-induced apoptosis.