학술논문
Benzodiazepine-insensitive mice generated by targeted disruption of the gamma2 subunit gene of gamma-aminobutyric acid type A receptor
Document Type
Academic Journal
Author
Source
Proceedings of the National Academy of Sciences of the United States. August 15, 1995, Vol. 92 Issue 17, p7749, 5 p. chart
Subject
Language
ISSN
0027-8424
Abstract
A study of the importance of benzodiazepine (BZ) site for brain development and function shows that gamma subunit can be omitted during the assembly of functional gamma-aminobutyric acid type A {GABA(sub A)} receptor but is necessary for normal channel conductance and formation of BZ sites. BZ site present extensively in prenatal rodent brain is not necessary for brain development. The experimental detail of the study is discussed.