학술논문
Role of external Na+ and cytosolic pH in agonist-evoked cytosolic Ca2+ response in human platelets
Document Type
Academic Journal
Author
Source
American Journal of Physiology (Consolidated). Dec 1994, Vol. 267 Issue 6, pC1543, 10 p.
Subject
Language
ISSN
0002-9513
Abstract
A study on the role of external Na+, Na+/H+ antiport and cytosolic pH in agonist-induced Ca2+ activation and Ca2+ entry in human platelets reveals that the thrombin-induced activation and entry of external Ca2+ are promoted by external Na+. Cytosolic alkalinization promotes the external Ca2+ entry, while agonist-induced Ca2+ activation cell entry occurs independent of Na+/H+ antiport.