학술논문
Nondisjunction--a view from Ringside
Document Type
Academic Journal
Author
Source
The New England Journal of Medicine. Nov 4, 2004, Vol. 351 Issue 19, p1931, 4 p.
Subject
Language
English
ISSN
0028-4793
Abstract
Chromosome nondisjunction is an improper segregation of chromosomes during meiosis that leads to chromosomally unbalanced eggs or sperm resulting in anueploidy that ultimately accounts for the main reason of fetal loss. Mapping recombination sites in normal and abnormal meioses has made it clear that altered recombination is a major contributor to nondisjunction in humans.