학술논문
Detergent-dependent dissociation of active gama-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex
Document Type
Academic Journal
Author
Source
Biochemistry. Jan 20, 2004, Vol. 43 Issue 2, p323
Subject
Language
English
ISSN
0006-2960
Abstract
Detailed information about the structural organization of the active gama-secretase complex, an important issue in dissecting the biochemistry of gama-secretase, is described. Four membrane proteins as components of gama-secretase are identified as components of gama-secretase, a heterodimeric form of presenilin (PS), composed of its N- and C-terminal fragments (PS-NTF and PS-CTF respectively), a highly glycosylated, mature form of nicastrin (NCT), Aph-1, and Pen-2.