부산대학교 도서관

Adiposis is reputed as a twin disease of type 2 diabetes andgreatly harmful to human health. In order to understand themolecular mechanisms of adiposis, the changes of physiological,pathological, epigenetic and correlative gene expression wereinvestigated during the adiposis development of C57BL/6J miceinduced by long time (9 months) high-fat and high-sucrose diet(HFSD) sustainably. The results showed that mRNA transcriptionlevel of the Leptin, Glut4 and Glut2 genes have been obviouslychanged, which exhibit a negative correlation with methylationon their promoter DNA. The results also revealed that HFSDinduced higher level of DNA methyltransferase 1 (DNMT1) in fattissue might play important role in regulating the changes ofmethylation pattern on Glut4 and Leptin genes, and which mightbe one of the molecular mechanisms for the adiposisdevelopment.