학술논문
Discovery of (S)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain
Document Type
Article
Author
Luo, G.; Chen, L.; Ditta, J.; Bronson, J.J.; MacOr, J.E.; Dzierba, C.D.; Kostich, W.A.; Easton, A.; Bourin, C.; Gulianello, M.; Conway, C.M.; Li, Y.-W.; Pieschl, R.; Tian, Y.; Hong, Y.; Bristow, L.; Albright, C.F.; Hamman, B.; Allen, J.; Wilson, A.; Gopinathan, S.; Wason, S.; Lippy, J.; Nara, S.; Maishal, T.K.; Thiyagarajan, K.; Jalagam, P.; Pattipati, S.N.; Dandapani, K.; Dokania, M.; Vattikundala, P.; Sharma, V.; Elavazhagan, S.; Verma, M.K.; Das, M.L.; Wagh, S.; Saminathan, H.; Holenarsipur, V.K.; Kumar, A.; Rao, A.; Putlur, S.P.; Sarvasiddhi, S.K.; Shankar, G.; Louis, J.V.; Ramarao, M.; Vetrichelvan, M.; Gupta, A.; Balakrishnan, A.; Johnson, B.M.; Santone, K.S.; Thalody, G.; Denton, R.; Mathur, A.; Li, J.; Smith, D.; Pawluczyk, J.; Sun, D.; Yip, S.; Wu, D.-R.
Source
In: Journal of Medicinal Chemistry . (Journal of Medicinal Chemistry, 24 March 2022, 65(6):4457-4480)
Subject
Language
English
ISSN
15204804
00222623
00222623