학술논문

Synthetic Morphogenesis: Introducing IEEE Journal Readers to Programming Living Mammalian Cells to Make Structures
Document Type
Periodical
Author
Source
Proceedings of the IEEE Proc. IEEE Proceedings of the IEEE. 110(5):688-707 May, 2022
Subject
General Topics for Engineers
Engineering Profession
Aerospace
Bioengineering
Components, Circuits, Devices and Systems
Computing and Processing
Engineered Materials, Dielectrics and Plasmas
Fields, Waves and Electromagnetics
Geoscience
Nuclear Engineering
Robotics and Control Systems
Signal Processing and Analysis
Transportation
Power, Energy and Industry Applications
Communication, Networking and Broadcast Technologies
Photonics and Electrooptics
Synthetic biology
Self-organizing networks
Electrooptics
Biological tissues
Embryo
Circuits and systems
Biomedical engineering
circuits and systems
construction
electrooptics
synthetic biology
Language
ISSN
0018-9219
1558-2256
Abstract
Synthetic morphogenesis is a new engineering discipline, in which cells are genetically engineered to make designed shapes and structures. At least in this early phase of the field, devices tend to make use of natural shape-generating processes that operate in embryonic development but invoke them artificially at times and in orders of a technologist’s choosing. This requires the construction of genetic control, sequencing, and feedback systems that have close parallels to electronic design, which is one reason the field may be of interest to readers of IEEE journals. The other reason is that synthetic morphogenesis allows the construction of two-way interfaces, especially optogenetic and optoelectronic, between the living and the electronic, allowing unprecedented information flow and control between the two types of “machines.” This review introduces synthetic morphogenesis, illustrates what has been achieved, drawing parallels wherever possible between biology and electronics, and looks forward to likely next steps and challenges to be overcome.