학술논문

Model Predictive Control for Real-Time Tumor Motion Compensation in Adaptive Radiotherapy
Document Type
Periodical
Source
IEEE Transactions on Control Systems Technology IEEE Trans. Contr. Syst. Technol. Control Systems Technology, IEEE Transactions on. 22(2):635-651 Mar, 2014
Subject
Signal Processing and Analysis
Communication, Networking and Broadcast Technologies
Computing and Processing
Robotics and Control Systems
Adaptive radiotherapy
model predictive control (MPC)
patient support systems (PSS)
real-time tumor motion compensation
Language
ISSN
1063-6536
1558-0865
2374-0159
Abstract
This paper presents the development and real-time implementation of a control system to automatically adjust the patient support system (PSS) position, thereby compensating for tumor motion caused by respiration and patient movements during radiotherapy treatment. The control scheme utilizes an observer to estimate the PSS state feedback, and a tumor position prediction algorithm to provide the reference for a model predictive controller. The real-time control algorithm was implemented using the Matlab and Simulink environments, with the communication with the clinical PSS performed through the dSPACE real-time system. The controller was shown to be able to position the PSS accurately and was able to track and compensate for organ motion with an accuracy of less than 1 mm in terms of root mean square error, giving rise to dose distributions indistinguishable from a static beam on a fixed target. From a clinical perspective, the increased targeting accuracy will enable an increased dose to the tumor without compromising the surrounding healthy tissues.