학술논문
Correlation of aberrant methylation of p16 gene to MTHFR C677T genetic polymorphisms in Hepatic Carcinoma
Document Type
Conference
Author
Source
2012 International Symposium on Information Technologies in Medicine and Education Information Technology in Medicine and Education (ITME), 2012 International Symposium on. 2:809-812 Aug, 2012
Subject
Language
Abstract
Object: To investigate the association between aberrant hypermethylation of p16 gene and methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms in Hepatic Carcinoma. Method: Hepatic Carcinoma cancer tissues and paracancerous normal tissues were collected. CpG island methylation status of p16 gene and MTHFR gene polymorphisms were analyzed by Real-time quantitative polymerase chain reaction (Real-time PCR). The associations between methylation status of P16 gene and clinical characteristics as well as MTHFR C677T polymorphisms were analyzed. Results: Among 86 HCC patients, the berrant hypermethylation rate of P16 gene was 60.5% in cancer tissues and 2.3% in paracancerou normal tissues. The aberrant hypermethylation rate of p16 gene in tumorous tissues was significantly higher than that in paracancerou normal tissues (χ 2 =67.48, p