학술논문
AP-1 Network Shared in Pathways of Rheumatoid Arthritis Subtyped Liver-kidney Deficiency Characterize the Pathology
Document Type
Conference
Author
Source
2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) Bioinformatics and Biomedicine (BIBM), 2023 IEEE International Conference on. :3493-3498 Dec, 2023
Subject
Language
ISSN
2156-1133
Abstract
Differentially expressed genes (DEGs) shared among different yet associated pathways on rheumatoid arthritis (RA) may shed light on its pathology study. In this study, DEGs of RA subtyped liver-kidney deficiency (a syndrome in traditional Chinese medicine) were collected from the GSE205962 dataset toward the roles they played among RA-associated pathways. GWAS (genome-wide association study) and enrichment analysis demonstrated that the AP-1 transcription factor-associated genes are the top DEGs shared by the RA-associated pathways. As a result, the AP-1 delivers complex regulations on immune responses e.g. activating T cells via up-regulating JUN, FOS, MAPKs, and NFKB1B while inhibiting IKBKB, LCK, NFKB1, CD3D, et al. The protein networks of DEGs shared in the T cell receptor signaling pathway and Th17 cell differentiation, together with the AP-1-centered network, were proposed.