학술논문

A Reconfigurable Tri-Mode Frequency-Locked Loop Readout Circuit for Biosensor Interfaces
Document Type
Periodical
Source
IEEE Transactions on Biomedical Circuits and Systems IEEE Trans. Biomed. Circuits Syst. Biomedical Circuits and Systems, IEEE Transactions on. 17(4):768-781 Aug, 2023
Subject
Bioengineering
Components, Circuits, Devices and Systems
Voltage-controlled oscillators
Frequency locked loops
Temperature measurement
Biosensors
CMOS process
Reconfigurable architectures
FLL
pH
potentiostat
sensors
temperature
Language
ISSN
1932-4545
1940-9990
Abstract
In this article, a frequency-locked loop (FLL) based multimodal readout integrated circuit (IC) for interfacing with off-chip temperature, electrochemical, and pH sensors is presented. By reconfiguring its switched-capacitor feedback network, the readout circuit is able to measure resistance, current, and voltage without additional active analog front-end circuits. A prototype IC was fabricated in a 0.18 μm CMOS process. Measured results show that when measuring resistance, the input-referred resistance resolution is 10.5$\Omega$ for 100 Hz integration bandwidth. Using an off-chip thermistor, the readout circuit covers a temperature range of 0–75 $^{\circ }$C and achieves an equivalent temperature resolution of 16.4 mK rms . In current mode, the readout circuit has an input range of 0.5μA and an input-referred current noise as low as 40.6 pA rms for 100 Hz bandwidth. Interfacing with an on-chip potentiostat, glucose chronoamperometry is demonstrated. In voltage mode, a minimum input-referred voltage noise of 31.7 μV rms is achieved, and the IC can measure a pH range from 1.6 to 12 using a commercial pH probe. At a 1.2 V supply, power consumption of the readout circuit is below 10 μW for all three measurement modes. Additionally, the prototype IC includes an integrated wireless transmitter that implements on-off keying modulation, and a wireless multimodal sensing system utilizing the FLL-based readout circuit is demonstrated.