학술논문
Multicellular PD Control in Microbial Consortia
Document Type
Periodical
Author
Source
IEEE Control Systems Letters IEEE Control Syst. Lett. Control Systems Letters, IEEE. 7:2641-2646 2023
Subject
Language
ISSN
2475-1456
Abstract
We propose a multicellular implementation of a biomolecular PD feedback controller to regulate gene expression in a microbial consortium. The implementation involves distributing the proportional and derivative control actions between two different cellular populations that can communicate with each other and regulate the output of a third target cellular population. We derive analytical conditions on biological parameters and control gains to adjust the system’s static and dynamical properties. We then validate the strategy’s performance and robustness through extensive in silico experiments.