학술논문
Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis
Document Type
article
Author
Navin P. Boeddha, MD, PhD; Gertjan J. Driessen, MD, PhD; Nienke N. Hagedoorn, MD; Daniela S. Kohlfuerst, MD; Clive J. Hoggart, PhD; Angelique L. van Rijswijk, MSc; Ebru Ekinci, MD; Debby Priem, BSc; Luregn J. Schlapbach, MD, PhD; Jethro A. Herberg, MD, PhD; Ronald de Groot, MD, PhD; Suzanne T. Anderson, MD, PhD; Colin G. Fink, PhD; Enitan D. Carrol, MD, PhD; Michiel van der Flier, MD, PhD; Federico Martinón-Torres, MD, PhD; Michael Levin, MD, PhD; Frank W. Leebeek, MD, PhD; Werner Zenz, MD, PhD; Moniek P. M. de Maat, PhD; Jan A. Hazelzet, MD, PhD; Marieke Emonts, MD, PhD; Willem A. Dik, PhD; on behalf of the EUCLIDS consortium; Michael Levin; Lachlan Coin; Stuart Gormley; Shea Hamilton; Jethro Herberg; Bernardo Hourmat; Clive Hoggart; Myrsini Kaforou; Vanessa Sancho-Shimizu; Victoria Wright; Amina Abdulla; Paul Agapow; Maeve Bartlett; Evangelos Bellos; Hariklia Eleftherohorinou; Rachel Galassini; David Inwald; Meg Mashbat; Stefanie Menikou; Sobia Mustafa; Simon Nadel; Rahmeen Rahman; Clare Thakker; S Bokhandi; Sue Power; Heather Barham; N Pathan; Jenna Ridout; Deborah White; Sarah Thurston; S Faust; S Patel; Jenni McCorkell; P Davies; Lindsey Crate; Helen Navarra; Stephanie Carter; R Ramaiah; Rekha Patel; Catherine Tuffrey; Andrew Gribbin; Sharon McCready; Mark Peters; Katie Hardy; Fran Standing; Lauren O’Neill; Eugenia Abelake; Akash Deep; Eniola Nsirim; A Pollard; Louise Willis; Zoe Young; C Royad; Sonia White; PM Fortune; Phil Hudnott; Federico Martinón-Torres; Antonio Salas; Fernando Álvez González; Ruth Barral-Arca; Miriam Cebey-López; María José CurrasTuala; Natalia García; Luisa García Vicente; Alberto Gómez-Carballa; Jose Gómez Rial; Andrea Grela Beiroa; Antonio Justicia Grande; Pilar Leboráns Iglesias; Alba Elena Martínez Santos; Nazareth Martinón-Torres; José María Martinón Sánchez; Beatriz Morillo Gutiérrez; Belén Mosquera Pérez; Pablo Obando Pacheco; Jacobo Pardo-Seco; Sara Pischedda; Irene Rivero Calle; Carmen Rodríguez-Tenreiro; Lorenzo Redondo-Collazo; Antonio Salas Ellacuriaga; Sonia Serén Fernández; María del Sol Porto Silva; Ana Vega; Lucía Vilanova Trillo; Susana Beatriz Reyes; María Cruz León León; Álvaro Navarro Mingorance; Xavier Gabaldó Barrios; Eider Oñate Vergara; Andrés Concha Torre; Ana Vivanco; Reyes Fernández; Francisco Giménez Sánchez; Miguel Sánchez Forte; Pablo Rojo; J.Ruiz Contreras; Alba Palacios; Cristina Epalza Ibarrondo; Elizabeth Fernández Cooke; Marisa Navarro; Cristina Álvarez Álvarez; María José Lozano; Eduardo Carreras; Sonia Brió Sanagustín; Olaf Neth; Mª del Carmen Martínez Padilla; Luis Manuel Prieto Tato; Sara Guillén; Laura Fernández Silveira; David Moreno; R. de Groot; A.M. Tutu van Furth; M. van der Flier; N.P. Boeddha; G.J.A. Driessen; M. Emonts; J.A. Hazelzet; T.W. Kuijpers; D. Pajkrt; E.A.M. Sanders; D. van de Beek; A. van der Ende; H.L.A. Philipsen; A.O.A. Adeel; M.A. Breukels; D.M.C. Brinkman; C.C.M.M. de Korte; E. de Vries; W.J. de Waal; R. Dekkers; A. Dings-Lammertink; R.A. Doedens; A.E. Donker; M. Dousma; T.E. Faber; G.P.J.M. Gerrits; J.A.M. Gerver; J. Heidema; J. Homan-van der Veen; M.A.M. Jacobs; N.J.G. Jansen; P. Kawczynski; K. Klucovska; M.C.J. Kneyber; Y. Koopman-Keemink; V.J. Langenhorst; J. Leusink; B.F. Loza; I.T. Merth; C.J. Miedema; C. Neeleman; J.G. Noordzij; C.C. Obihara; A.L.T. van Overbeek – van Gils; G.H. Poortman; S.T. Potgieter; J. Potjewijd; P.P.R. Rosias; T. Sprong; G.W. ten Tussher; B.J. Thio; G.A. Tramper-Strander; M. van Deuren; H. van der Meer; A.J.M. van Kuppevelt; A.M. van Wermeskerken; W.A. Verwijs; T.F.W. Wolfs; Luregn J Schlapbach; Philipp Agyeman; Christoph Aebi; Eric Giannoni; Martin Stocker; Klara M Posfay-Barbe; Ulrich Heininger; Sara Bernhard-Stirnemann; Anita Niederer-Loher; Christian Kahlert; Paul Hasters; Christa Relly; Walter Baer; Christoph Berger; Enitan Carrol; Stéphane Paulus; Hannah Frederick; Rebecca Jennings; Joanne Johnston; Rhian Kenwright; Colin G Fink; Elli Pinnock; Marieke Emonts; Rachel Agbeko; Suzanne Anderson; Fatou Secka; Kalifa Bojang; Isatou Sarr; Ngane Kebbeh; Gibbi Sey; Momodou Saidykhan; Fatoumatta Cole; Gilleh Thomas; Martin Antonio; Werner Zenz; Daniela S. Klobassa; Alexander Binder; Nina A. Schweintzger; Manfred Sagmeister; Hinrich Baumgart; Markus Baumgartner; Uta Behrends; Ariane Biebl; Robert Birnbacher; Jan-Gerd Blanke; Carsten Boelke; Kai Breuling; Jürgen Brunner; Maria Buller; Peter Dahlem; Beate Dietrich; Ernst Eber; Johannes Elias; Josef Emhofer; Rosa Etschmaier; Sebastian Farr; Ylenia Girtler; Irina Grigorow; Konrad Heimann; Ulrike Ihm; Zdenek Jaros; Hermann Kalhoff; Wilhelm Kaulfersch; Christoph Kemen; Nina Klocker; Bernhard Köster; Benno Kohlmaier; Eleni Komini; Lydia Kramer; Antje Neubert; Daniel Ortner; Lydia Pescollderungg; Klaus Pfurtscheller; Karl Reiter; Goran Ristic; Siegfried Rödl; Andrea Sellner; Astrid Sonnleitner; Matthias Sperl; Wolfgang Stelzl; Holger Till; Andreas Trobisch; Anne Vierzig; Ulrich Vogel; Christina Weingarten; Stefanie Welke; Andreas Wimmer; Uwe Wintergerst; Daniel Wüller; Andrew Zaunschirm; Ieva Ziuraite; Veslava Žukovskaja
Source
Critical Care Explorations, Vol 3, Iss 11, p e0569 (2021)
Subject
Language
English
ISSN
2639-8028
00000000
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Abstract
IMPORTANCE:. A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 is hypothesized to play a role in the pathogenesis of invasive infection, but studies in sepsis are lacking. OBJECTIVES:. To study A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 protein level in pediatric sepsis and to study the association with outcome. DESIGN:. Data from two prospective cohort studies. SETTING AND PARTICIPANTS:. Cohort 1 is from a single-center study involving children admitted to PICU with meningococcal sepsis (samples obtained at three time points). Cohort 2 includes patients from a multicenter study involving children admitted to the hospital with invasive bacterial infections of differing etiologies (samples obtained within 48 hr after hospital admission). MAIN OUTCOMES AND MEASURES:. Primary outcome measure was mortality. Secondary outcome measures were PICU-free days at day 28 and hospital length of stay. RESULTS:. In cohort 1 (n = 59), nonsurvivors more frequently had A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels above the detection limit than survivors at admission to PICU (8/11 [73%] and 6/23 [26%], respectively; p = 0.02) and at t = 24 hours (2/3 [67%] and 3/37 [8%], respectively; p = 0.04). In cohort 2 (n = 240), A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels in patients within 48 hours after hospital admission were more frequently above the detection limit than in healthy controls (110/240 [46%] and 14/64 [22%], respectively; p = 0.001). Nonsurvivors more often had detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels than survivors (16/21 [76%] and 94/219 [43%], respectively; p = 0.003), which was mostly attributable to patients with Neisseria meningitidis. CONCLUSIONS AND RELEVANCE:. In children with bacterial infection, detection of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 within 48 hours after hospital admission is associated with death, particularly in meningococcal sepsis. Future studies should confirm the prognostic value of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 and should study pathophysiologic mechanisms.