학술논문
Functional respiratory complaints among COVID-19 survivors: a prospective cohort study
Document Type
article
Author
Antoine Beurnier; Laurent Savale; Xavier Jaïs; Romain Colle; Tai Pham; Luc Morin; Sophie Bulifon; Nicolas Noël; Athénaïs Boucly; Benoit Delbarre; Nathan Ebstein; Samy Figueiredo; Matthieu Gasnier; Anatole Harrois; Etienne-Marie Jutant; Mitja Jevnikar; Sophia Keddache; Anne-Lise Lecoq; Olivier Meyrignac; Florence Parent; Jérémie Pichon; Mariana Preda; Anne Roche; Andrei Seferian; Marie-France Bellin; Thomas Gille; Emmanuelle Corruble; Olivier Sitbon; Laurent Becquemont; Xavier Monnet; Marc Humbert; David Montani; and the Comebac Investigators
Source
ERJ Open Research, Vol 9, Iss 3 (2023)
Subject
Language
English
ISSN
2312-0541
23120541
23120541
Abstract
Background Dyspnoea is a common persistent symptom after COVID-19. Whether it is associated with functional respiratory disorders remains unclear. Methods We assessed the proportion and characteristics of patients with “functional respiratory complaints” (FRCs) (as defined by Nijmegen Questionnaire >22) among 177 post-COVID-19 individuals who benefited from outclinic evaluation in the COMEBAC study (i.e., symptomatic and/or intensive care unit (ICU) survivors at 4 months). In a distinct explanatory cohort of 21 consecutive individuals with unexplained post-COVID-19 dyspnoea after routine tests, we also analysed the physiological responses to incremental cardiopulmonary exercise testing (CPET). Findings In the COMEBAC cohort, 37 patients had significant FRCs (20.9%, IC95: 14.9–26.9). The prevalence of FRCs ranged from 7.2% (ICU patients) to 37.5% (non-ICU patients). The presence of FRCs was significantly associated with more severe dyspnoea, lower 6-min walk distance, more frequent psychological and neurological symptoms (cognitive complaint, anxiety, depression, insomnia and post-traumatic stress disorders) and poorer quality of life (all p