학술논문
Tissue engineered vascular grafts are resistant to the formation of dystrophic calcification
Document Type
article
Author
Mackenzie E. Turner; Kevin M. Blum; Tatsuya Watanabe; Erica L. Schwarz; Mahboubeh Nabavinia; Joseph T. Leland; Delaney J. Villarreal; William E. Schwartzman; Ting-Heng Chou; Peter B. Baker; Goki Matsumura; Rajesh Krishnamurthy; Andrew R. Yates; Kan N. Hor; Jay D. Humphrey; Alison L. Marsden; Mitchel R. Stacy; Toshiharu Shinoka; Christopher K. Breuer
Source
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Subject
Language
English
ISSN
2041-1723
Abstract
Abstract Advancements in congenital heart surgery have heightened the importance of durable biomaterials for adult survivors. Dystrophic calcification poses a significant risk to the long-term viability of prosthetic biomaterials in these procedures. Herein, we describe the natural history of calcification in the most frequently used vascular conduits, expanded polytetrafluoroethylene grafts. Through a retrospective clinical study and an ovine model, we compare the degree of calcification between tissue-engineered vascular grafts and polytetrafluoroethylene grafts. Results indicate superior durability in tissue-engineered vascular grafts, displaying reduced late-term calcification in both clinical studies (p