학술논문
A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
Document Type
article
Author
Camila H. Coelho; Wai Kwan Tang; Martin Burkhardt; Jacob D. Galson; Olga Muratova; Nichole D. Salinas; Thiago Luiz Alves e Silva; Karine Reiter; Nicholas J. MacDonald; Vu Nguyen; Raul Herrera; Richard Shimp; David L. Narum; Miranda Byrne-Steele; Wenjing Pan; Xiaohong Hou; Brittany Brown; Mary Eisenhower; Jian Han; Bethany J. Jenkins; Justin Y. A. Doritchamou; Margery G. Smelkinson; Joel Vega-Rodríguez; Johannes Trück; Justin J. Taylor; Issaka Sagara; Jonathan P. Renn; Niraj H. Tolia; Patrick E. Duffy
Source
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Vaccines that interrupt malaria transmission will be important tools for malaria elimination. Here the authors identify a human monoclonal antibody from Pfs230 vaccinated individuals that blocks transmission of Plasmodium falciparum to mosquitoes in a complement-dependent manner and reacts with gamete surface.