학술논문
The association between genetically elevated polyunsaturated fatty acids and risk of cancerResearch in context
Document Type
article
Author
Philip C. Haycock; Maria Carolina Borges; Kimberley Burrows; Rozenn N. Lemaitre; Stephen Burgess; Nikhil K. Khankari; Konstantinos K. Tsilidis; Tom R. Gaunt; Gibran Hemani; Jie Zheng; Therese Truong; Brenda M. Birmann; Tracy OMara; Amanda B. Spurdle; Mark M. Iles; Matthew H. Law; Susan L. Slager; Fatemeh Saberi Hosnijeh; Daniela Mariosa; Michelle Cotterchio; James R. Cerhan; Ulrike Peters; Stefan Enroth; Puya Gharahkhani; Loic Le Marchand; Ann C. Williams; Robert C. Block; Christopher I. Amos; Rayjean J. Hung; Wei Zheng; Marc J. Gunter; George Davey Smith; Caroline Relton; Richard M. Martin; Nathan Tintle; Terri Rice; Iona Cheng; Mark Jenkins; Steve Gallinger; Alex J. Cornish; Amit Sud; Jayaram Vijayakrishnan; Margaret Wrensch; Mattias Johansson; Aaron D. Norman; Alison Klein; Alyssa Clay-Gilmour; Andre Franke; Andres V. Ardisson Korat; Bill Wheeler; Björn Nilsson; Caren Smith; Chew-Kiat Heng; Ci Song; David Riadi; Elizabeth B. Claus; Eva Ellinghaus; Evgenia Ostroumova; Hosnijeh; Florent de Vathaire; Giovanni Cugliari; Giuseppe Matullo; Irene Oi-Lin Ng; Jeanette E. Passow; Jia Nee Foo; Jiali Han; Jianjun Liu; Jill Barnholtz-Sloan; Joellen M. Schildkraut; John Maris; Joseph L. Wiemels; Kari Hemminki; Keming Yang; Lambertus A. Kiemeney; Lang Wu; Laufey Amundadottir; Marc-Henri Stern; Marie-Christine Boutron; Mark Martin Iles; Mark P. Purdue; Martin Stanulla; Melissa Bondy; Mia Gaudet; Lenha Mobuchon; Nicola J. Camp; Pak Chung Sham; Pascal Guénel; Paul Brennan; Philip R. Taylor; Quinn Ostrom; Rachael Stolzenberg-Solomon; Rajkumar Dorajoo; Richard Houlston; Robert B. Jenkins; Sharon Diskin; Sonja I. Berndt; Spiridon Tsavachidis; Stephen J. Channock; Tabitha Harrison; Tessel Galesloot; Ulf Gyllensten; Vijai Joseph; Y. Shi; Wenjian Yang; Yi Lin; Stephen K. Van Den Eeden
Source
EBioMedicine, Vol 91, Iss , Pp 104510- (2023)
Subject
Language
English
ISSN
2352-3964
Abstract
Summary: Background: The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain. Methods: Using a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in European and East Asian ancestry individuals. We defined the primary exposure as PUFA desaturase activity, proxied by rs174546 at the FADS locus. Secondary exposures were defined as omega 3 and omega 6 PUFAs that could be proxied by genetic polymorphisms outside the FADS region. Our study used summary genetic data on 10 PUFAs and 67 cancers, corresponding to 562,871 cases and 1,619,465 controls, collected by the Fatty Acids in Cancer Mendelian Randomization Collaboration. We estimated odds ratios (ORs) for cancer per standard deviation increase in genetically proxied PUFA exposures. Findings: Genetically elevated PUFA desaturase activity was associated (P