학술논문
Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
Document Type
article
Author
Irma Karabegović; Eliana Portilla-Fernandez; Yang Li; Jiantao Ma; Silvana C. E. Maas; Daokun Sun; Emily A. Hu; Brigitte Kühnel; Yan Zhang; Srikant Ambatipudi; Giovanni Fiorito; Jian Huang; Juan E. Castillo-Fernandez; Kerri L. Wiggins; Niek de Klein; Sara Grioni; Brenton R. Swenson; Silvia Polidoro; Jorien L. Treur; Cyrille Cuenin; Pei-Chien Tsai; Ricardo Costeira; Veronique Chajes; Kim Braun; Niek Verweij; Anja Kretschmer; Lude Franke; Joyce B. J. van Meurs; André G. Uitterlinden; Robert J. de Knegt; M. Arfan Ikram; Abbas Dehghan; Annette Peters; Ben Schöttker; Sina A. Gharib; Nona Sotoodehnia; Jordana T. Bell; Paul Elliott; Paolo Vineis; Caroline Relton; Zdenko Herceg; Hermann Brenner; Melanie Waldenberger; Casey M. Rebholz; Trudy Voortman; Qiuwei Pan; Myriam Fornage; Daniel Levy; Manfred Kayser; Mohsen Ghanbari
Source
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
While coffee and tea consumption has been associated with risk of diseases, their mechanisms of action remain elusive. Here the authors present a large EWAS on coffee and tea consumption in cohorts of European and African-American ancestries, finding that coffee consumption is associated with differential DNA methylation levels at multiple CpGs.