학술논문
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations
Document Type
article
Author
Minta Thomas; Yu-Ru Su; Elisabeth A. Rosenthal; Lori C. Sakoda; Stephanie L. Schmit; Maria N. Timofeeva; Zhishan Chen; Ceres Fernandez-Rozadilla; Philip J. Law; Neil Murphy; Robert Carreras-Torres; Virginia Diez-Obrero; Franzel J. B. van Duijnhoven; Shangqing Jiang; Aesun Shin; Alicja Wolk; Amanda I. Phipps; Andrea Burnett-Hartman; Andrea Gsur; Andrew T. Chan; Ann G. Zauber; Anna H. Wu; Annika Lindblom; Caroline Y. Um; Catherine M. Tangen; Chris Gignoux; Christina Newton; Christopher A. Haiman; Conghui Qu; D. Timothy Bishop; Daniel D. Buchanan; David R. Crosslin; David V. Conti; Dong-Hyun Kim; Elizabeth Hauser; Emily White; Erin Siegel; Fredrick R. Schumacher; Gad Rennert; Graham G. Giles; Heather Hampel; Hermann Brenner; Isao Oze; Jae Hwan Oh; Jeffrey K. Lee; Jennifer L. Schneider; Jenny Chang-Claude; Jeongseon Kim; Jeroen R. Huyghe; Jiayin Zheng; Jochen Hampe; Joel Greenson; John L. Hopper; Julie R. Palmer; Kala Visvanathan; Keitaro Matsuo; Koichi Matsuda; Keum Ji Jung; Li Li; Loic Le Marchand; Ludmila Vodickova; Luis Bujanda; Marc J. Gunter; Marco Matejcic; Mark A. Jenkins; Martha L. Slattery; Mauro D’Amato; Meilin Wang; Michael Hoffmeister; Michael O. Woods; Michelle Kim; Mingyang Song; Motoki Iwasaki; Mulong Du; Natalia Udaltsova; Norie Sawada; Pavel Vodicka; Peter T. Campbell; Polly A. Newcomb; Qiuyin Cai; Rachel Pearlman; Rish K. Pai; Robert E. Schoen; Robert S. Steinfelder; Robert W. Haile; Rosita Vandenputtelaar; Ross L. Prentice; Sébastien Küry; Sergi Castellví-Bel; Shoichiro Tsugane; Sonja I. Berndt; Soo Chin Lee; Stefanie Brezina; Stephanie J. Weinstein; Stephen J. Chanock; Sun Ha Jee; Sun-Seog Kweon; Susan Vadaparampil; Tabitha A. Harrison; Taiki Yamaji; Temitope O. Keku; Veronika Vymetalkova; Volker Arndt; Wei-Hua Jia; Xiao-Ou Shu; Yi Lin; Yoon-Ok Ahn; Zsofia K. Stadler; Bethany Van Guelpen; Cornelia M. Ulrich; Elizabeth A. Platz; John D. Potter; Christopher I. Li; Reinier Meester; Victor Moreno; Jane C. Figueiredo; Graham Casey; Iris Lansdorp Vogelaar; Malcolm G. Dunlop; Stephen B. Gruber; Richard B. Hayes; Paul D. P. Pharoah; Richard S. Houlston; Gail P. Jarvik; Ian P. Tomlinson; Wei Zheng; Douglas A. Corley; Ulrike Peters; Li Hsu
Source
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Abstract Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values