학술논문
Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count
Document Type
article
Author
María J. Ruiz-de-León; María A. Jiménez-Sousa; Santiago Moreno; Marcial García; Mónica Gutiérrez-Rivas; Agathe León; Marta Montero-Alonso; Juan González-García; Salvador Resino; Norma Rallón; José M. Benito; Alejandro Vallejo; J.M. Benito; N. Rallón; C. Restrepo; N. Rodríguez; M. García; A. Cabello; M. Gorgolas; S. Resino; V. Briz; M.A. Jiménez; M.S. Vázquez; A. Fernández; P. García; M.A. Muñoz; J. Sánchez; J.L. Jiménez; D. Sepúlveda; I. García; I. Consuegra; A. León; M. Arnedo; M. Plana; N. Climent; F. García; E. Ruiz-Mateos; B. Domínguez; L. Tarancón; M. Rafii-El-Idrissi; M.J. Polaino; M. Genebat; P. Viciana; M. Leal; F. Vidal; E. Rodríguez; C. Viladés; J. Peraire; J. Romero; C Rodríguez; M. Vera; J. Esté; E. Ballana; M.A. Martínez; S. Franco; M. Nevot; A. Vallejo; S. Moreno; M. Pernas; C. Casado; C. López; L. Capa; M. Pérez; J. Alcami; R. Sanjuán; J.M. Cueva; R. Delgado; O. Sierra; A. Valenzuela
Source
Journal of Microbiology, Immunology and Infection, Vol 52, Iss 4, Pp 667-671 (2019)
Subject
Language
English
ISSN
1684-1182
Abstract
Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137–0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = −0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found. Keywords: Exosomes, miRNAs, HIV-1, Elite controllers, Immune activation, Soluble biomarkers