학술논문
Association of allergies in children younger than 3 years with levels of maternal intake of n-3 polyunsaturated fatty acids or fish during pregnancy: A nationwide birth cohort study, the Japan Environment and Children's Study
Document Type
article
Author
Sayaka Tsuji; Yuichi Adachi; Akiko Tsuchida; Kei Hamazaki; Kenta Matsumura; Hidekuni Inadera; Michihiro Kamijima; Shin Yamazaki; Yukihiro Ohya; Reiko Kishi; Nobuo Yaegashi; Koichi Hashimoto; Chisato Mori; Shuichi Ito; Zentaro Yamagata; Takeo Nakayama; Tomotaka Sobue; Masayuki Shima; Seiji Kageyama; Narufumi Suganuma; Shoichi Ohga; Takahiko Katoh
Source
Allergology International, Vol 73, Iss 2, Pp 282-289 (2024)
Subject
Language
English
ISSN
1323-8930
Abstract
Background: N-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory properties and are expected to prevent the onset of allergies. However, epidemiological studies investigating the relationship between child allergies and maternal intake of n-3 PUFAs or fish have yielded inconsistent results. Methods: Following exclusions from a dataset comprising 103,057 records from the Japan Environment and Children's Study, 72,105 participants were divided into five groups according to mothers' intake of n-3 PUFAs or fish during pregnancy to assess the risk of their children being diagnosed with allergy by 3 years old. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for child allergies were calculated using multivariable logistic regression analyses with reference to the lowest intake group. Results: Levels of maternal intake of n-3 PUFAs or fish showed inverted associations (i.e., reduced risk) with the incidence of physician-diagnosed allergic rhinoconjunctivitis or parent-reported symptoms of current rhinitis with eye symptoms at different time points and the cumulative incidence from birth to 3 years of age. Inverted associations were also found for current wheeze at 1-