학술논문
The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression
Document Type
article
Author
Yashar S. Niknafs; Sumin Han; Teng Ma; Corey Speers; Chao Zhang; Kari Wilder-Romans; Matthew K. Iyer; Sethuramasundaram Pitchiaya; Rohit Malik; Yasuyuki Hosono; John R. Prensner; Anton Poliakov; Udit Singhal; Lanbo Xiao; Steven Kregel; Ronald F. Siebenaler; Shuang G. Zhao; Michael Uhl; Alexander Gawronski; Daniel F. Hayes; Lori J. Pierce; Xuhong Cao; Colin Collins; Rolf Backofen; Cenk S. Sahinalp; James M. Rae; Arul M. Chinnaiyan; Felix Y. Feng
Source
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
LncRNAs have been associated with cancer. Here, the authors carry out a systematic review of lncRNAs in breast cancer and show that DSCAM-AS1is highly expressed in oestrogen receptor positive tumours and enhances cancer through an interaction with hnRNPL; and is also associated with tamoxifen resistance.