학술논문
Effects of levothyroxine substitution therapy on hunger and food intake in individuals with hypothyroidism
Document Type
article
Author
Source
Endocrine Connections, Vol 12, Iss 10, Pp 1-14 (2023)
Subject
Language
English
ISSN
2049-3614
Abstract
Context: In individuals with hypothyroidism and overweight, levothyroxine substitution therapy is often expected to cause weight loss due to its effect on resting energy expenditure. However, despite levothyroxine-induced enhancement of resting energy expenditure, fat mass loss is rarely seen after levothyroxine substitution therapy. The mechanism behind this conundrum is unknown. Aim: The aim of the study was to assess the effect of levothyroxine t herapy on hunger sensations and ad libitum food intake in individuals with hypothyroidism. Design and setting: Prospective cohort study of 18 newly diagnosed hypothyroid women (thyroid-stimulating hormone (TSH) >10 mU/L). Participants were investigated at diagnosis, after normalization of TSH (