학술논문
A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts
Document Type
article
Author
Fergal J. Duffy; Ethan Thompson; Katrina Downing; Sara Suliman; Harriet Mayanja-Kizza; W. Henry Boom; Bonnie Thiel; January Weiner III; Stefan H. E. Kaufmann; Drew Dover; David L. Tabb; Hazel M. Dockrell; Tom H. M. Ottenhoff; Gerard Tromp; Thomas J. Scriba; Daniel E. Zak; Gerhard Walzl; the GC6-74 Consortium; S. H. E. Kaufmann; S. K. Parida; R. Golinski; J. Maertzdorf; J. Weiner; M. Jacobson; G. McEwen; G. Walzl; G. Black; G. van der Spuy; K. Stanley; M. Kriel; N. Du Plessis; N. Nene; A. Loxton; N. N. Chegou; S. Suliman; T. Scriba; H. Mahomed; M. Erasmus; O. Xasa; A. Veldsman; J. Hughes; K. Downing; A. Penn-Nicholson; H. Mulenga; B. Abel; M. Bowmaker; B. Kagina; W. Kwong C; W. Hanekom; T. H. M. Ottenhoff; M. R. Klein; M. C. Haks; K. L. Franken; A. Geluk; K. E. van Meijgaarden; S. A. Joosten; D. van Baarle; F. Miedema; W. H. Boom; B. Thiel; J. Sadoff; D. Sizemore; S. Ramachandran; L. Barker; M. Brennan; F. Weichold; S. Muller; L. Geiter; G. Schoolnik; G. Dolganov; T. Van; H. Mayanja-Kizza; M. Joloba; S. Zalwango; M. Nsereko; B. Okwera; H. Kisingo; H. Dockrell; S. Smith; P. Gorak-Stolinska; Y.-G. Hur; M. Lalor; J.-S. Lee; A. C. Crampin; N. French; B. Ngwira; A. B. Smith; K. Watkins; L. Ambrose; F. Simukonda; H. Mvula; F. Chilongo; J. Saul; K. Branson; D. Kassa; A. Abebe; T. Mesele; B. Tegbaru; R. Howe; A. Mihret; A. Aseffa; Y. Bekele; R. Iwnetu; M. Tafesse; L. Yamuah; M. Ota; J. Sutherland; P. Hill; R. Adegbola; T. Corrah; M. Antonio; T. Togun; I. Adetifa; S. Donkor; P. Andersen; I. Rosenkrands; M. Doherty; K. Weldingh
Source
Frontiers in Immunology, Vol 9 (2018)
Subject
Language
English
ISSN
1664-3224
Abstract
Biomarkers that predict who among recently Mycobacterium tuberculosis (MTB)-exposed individuals will progress to active tuberculosis are urgently needed. Intracellular microRNAs (miRNAs) regulate the host response to MTB and circulating miRNAs (c-miRNAs) have been developed as biomarkers for other diseases. We performed machine-learning analysis of c-miRNA measurements in the serum of adult household contacts (HHCs) of TB index cases from South Africa and Uganda and developed a c-miRNA-based signature of risk for progression to active TB. This c-miRNA-based signature significantly discriminated HHCs within 6 months of progression to active disease from HHCs that remained healthy in an independent test set [ROC area under the ROC curve (AUC) 0.74, progressors