학술논문
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
Document Type
article
Author
Viktoria Gusarova; Colm O’Dushlaine; Tanya M. Teslovich; Peter N. Benotti; Tooraj Mirshahi; Omri Gottesman; Cristopher V. Van Hout; Michael F. Murray; Anubha Mahajan; Jonas B. Nielsen; Lars Fritsche; Anders Berg Wulff; Daniel F. Gudbjartsson; Marketa Sjögren; Connor A. Emdin; Robert A. Scott; Wen-Jane Lee; Aeron Small; Lydia C. Kwee; Om Prakash Dwivedi; Rashmi B. Prasad; Shannon Bruse; Alexander E. Lopez; John Penn; Anthony Marcketta; Joseph B. Leader; Christopher D. Still; H. Lester Kirchner; Uyenlinh L. Mirshahi; Amr H. Wardeh; Cassandra M. Hartle; Lukas Habegger; Samantha N. Fetterolf; Teresa Tusie-Luna; Andrew P. Morris; Hilma Holm; Valgerdur Steinthorsdottir; Patrick Sulem; Unnur Thorsteinsdottir; Jerome I. Rotter; Lee-Ming Chuang; Scott Damrauer; David Birtwell; Chad M. Brummett; Amit V. Khera; Pradeep Natarajan; Marju Orho-Melander; Jason Flannick; Luca A. Lotta; Cristen J. Willer; Oddgeir L. Holmen; Marylyn D. Ritchie; David H. Ledbetter; Andrew J. Murphy; Ingrid B. Borecki; Jeffrey G. Reid; John D. Overton; Ola Hansson; Leif Groop; Svati H. Shah; William E. Kraus; Daniel J. Rader; Yii-Der I. Chen; Kristian Hveem; Nicholas J. Wareham; Sekar Kathiresan; Olle Melander; Kari Stefansson; Børge G. Nordestgaard; Anne Tybjærg-Hansen; Goncalo R. Abecasis; David Altshuler; Jose C. Florez; Michael Boehnke; Mark I. McCarthy; George D. Yancopoulos; David J. Carey; Alan R. Shuldiner; Aris Baras; Frederick E. Dewey; Jesper Gromada
Source
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Genetic variation in ANGPTL4 is associated with lipid traits. Here, the authors find that predicted loss-of-function variants in ANGPTL4 are associated with glucose homeostasis and reduced risk of type 2 diabetes and that Angptl4 −/− mice on a high-fat diet show improved insulin sensitivity.