학술논문
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus
Document Type
article
Author
Adrienne Tin; Pascal Schlosser; Pamela R. Matias-Garcia; Chris H. L. Thio; Roby Joehanes; Hongbo Liu; Zhi Yu; Antoine Weihs; Anselm Hoppmann; Franziska Grundner-Culemann; Josine L. Min; Victoria L. Halperin Kuhns; Adebowale A. Adeyemo; Charles Agyemang; Johan Ärnlöv; Nasir A. Aziz; Andrea Baccarelli; Murielle Bochud; Hermann Brenner; Jan Bressler; Monique M. B. Breteler; Cristian Carmeli; Layal Chaker; Josef Coresh; Tanguy Corre; Adolfo Correa; Simon R. Cox; Graciela E. Delgado; Kai-Uwe Eckardt; Arif B. Ekici; Karlhans Endlich; James S. Floyd; Eliza Fraszczyk; Xu Gao; Xīn Gào; Allan C. Gelber; Mohsen Ghanbari; Sahar Ghasemi; Christian Gieger; Philip Greenland; Megan L. Grove; Sarah E. Harris; Gibran Hemani; Peter Henneman; Christian Herder; Steve Horvath; Lifang Hou; Mikko A. Hurme; Shih-Jen Hwang; Sharon L. R. Kardia; Silva Kasela; Marcus E. Kleber; Wolfgang Koenig; Jaspal S. Kooner; Florian Kronenberg; Brigitte Kühnel; Christine Ladd-Acosta; Terho Lehtimäki; Lars Lind; Dan Liu; Donald M. Lloyd-Jones; Stefan Lorkowski; Ake T. Lu; Riccardo E. Marioni; Winfried März; Daniel L. McCartney; Karlijn A. C. Meeks; Lili Milani; Pashupati P. Mishra; Matthias Nauck; Christoph Nowak; Annette Peters; Holger Prokisch; Bruce M. Psaty; Olli T. Raitakari; Scott M. Ratliff; Alex P. Reiner; Ben Schöttker; Joel Schwartz; Sanaz Sedaghat; Jennifer A. Smith; Nona Sotoodehnia; Hannah R. Stocker; Silvia Stringhini; Johan Sundström; Brenton R. Swenson; Joyce B. J. van Meurs; Jana V. van Vliet-Ostaptchouk; Andrea Venema; Uwe Völker; Juliane Winkelmann; Bruce H. R. Wolffenbuttel; Wei Zhao; Yinan Zheng; The Estonian Biobank Research Team; The Genetics of DNA Methylation Consortium; Marie Loh; Harold Snieder; Melanie Waldenberger; Daniel Levy; Shreeram Akilesh; Owen M. Woodward; Katalin Susztak; Alexander Teumer; Anna Köttgen
Source
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Serum urate concentration can be studied in large datasets to find genetic and epigenetic loci that may be related to cardiometabolic traits. Here the authors identify and replicate 100 urate-associated CpGs, which provide insights into urate GWAS loci and shared CpGs of urate and cardiometabolic traits.