학술논문
Assessment of 28-Day In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019: An International Cohort Study
Document Type
article
Author
Gianluigi Li Bassi, MD, PhD; Jacky Y. Suen, BSc, PhD; Nicole White, PhD; Heidi J. Dalton, MD, MCCM; Jonathon Fanning, BSc, MBBS, PhD, FANZCA, FCICM; Amanda Corley, RN; Sally Shrapnel, MBBS, BMedSc, MSc, PhD, FRACGP; Samuel Hinton, PhD; Simon Forsyth, PhD; Rex Parsons, BSc, MMedStats; John G. Laffey, MD; Eddy Fan, MD, PhD; Robert Bartlett, MD; Daniel Brodie, MD; Aidan Burrell, MD, PhD; Davide Chiumello, MD; Alyaa Elhazmi, MD; Giacomo Grasselli, MD; Carol Hodgson, PT, PhD; Shingo Ichiba, MD; Carlos Luna, MD; Eva Marwali, MD; Laura Merson, Bsc; Srinivas Murthy, MD; Alistair Nichol, MD, PhD; Mauro Panigada, MD; Paolo Pelosi, MD, FERS; Antoni Torres, MD, PhD, FERS; Pauline Yeung Ng, MD; Mark Ogino, MD; John F. Fraser, MBChB, PhD, FRCP(Glas), FFARCSI, FRCA, FCICM; on behalf of the COVID-19 Critical Care Consortium; Tala Al-Dabbous; Huda Alfoudri; Mohammed Shamsah; Subbarao Elapavaluru; Ashley Berg; Christina Horn; Stephan Schroll; Jorge Velazco; Ludmyla Ploskanych; Wanda Fikes; Dan Meyer; Ashley Ehlers; Maysoon Shalabi-McGuire; Trent Witt; Lorenzo Grazioli; Luca Lorini; E. Wilson Grandin; Jose Nunez; Tiago Reyes; Diarmuid O’Briain; Stephanie Hunter; Mahesh Ramanan; Julia Affleck; Hemanth Hurkadli Veerendra; Sumeet Rai; Josie Russell-Brown; Mary Nourse; Mark Joseph; Brook Mitchell; Martha Tenzer; Carilion Clinic; Ryuzo Abe; Hwa Jin Cho; In Seok Jeong; Nicolas Brozzi; Omar Mehkri; Sudhir Krishnan; Abhijit Duggal; Stuart Houltham; Jerónimo Graf; Roderigo Diaz; Camila Delgado; Joyce González; Maria Soledad Sanchez; Diego Fernando Bautista Rincón; Angela Maria Marulanda Yanten; Melissa Bustamante Duque; Daniel Brodie; Desy Rusmawatiningtyas; Maria Callahan; M. Azhari Taufik; Elizabeth Yasmin Wardoyo; Margaretha Gunawan; Nurindah S Trisnaningrum; Vera Irawany; Muhammad Rayhan; Mauro Panigada; Antonia Pesenti; Alberto Zanella; Michela Leone; Giacomo Grasselli; Silvia Coppola; Sebastiano Colombo; Massimo Antonelli; Simone Carelli; Domenico L. Grieco; Motohiro Asaki; Kota Hoshino; Leonardo Salazar; Laura Duarte; John Laffey; Bairbre McNicholas; David Cosgrave; Joseph McCaffrey; Allison Bone; Yusuff Hakeem; James Winearls; Mandy Tallott; David Thomson; Christel Arnold-Day; Jerome Cupido; Zainap Fanie; Malcom Miller; Lisa Seymore; Dawid van Straaten; Ali Ait Hssain; Jeffrey Aliudin; Al-Reem Alqahtani; Khoulod Mohamed; Ahmed Mohamed; Darwin Tan; Joy Villanueva; Ahmed Zaqout; Ethan Kurtzman; Arben Ademi; Ana Dobrita; Khadija El Aoudi; Juliet Segura; Gezy Giwangkancana; Shinichiro Ohshimo; Koji Hoshino; Saito Hitoshi; Javier Osatnik; Anne Joosten; Antoni Torres; Minlan Yang; Ana Motos; Carlos Luna; Francisco Arancibia; Virginie Williams; Alexandre Noel; Nestor Luque; Trieu Huynh Trung; Sophie Yacoub; Marina Fantini; Ruth Noemi Jorge García; Enrique Chicote Alvarez; Anna Greti; Adrian Ceccato; Angel Sanchez; Ana Loza Vazquez; Ferran Roche-Campo; Diego Franch-Llasat; Divina Tuazon; Marcelo Amato; Luciana Cassimiro; Flavio Pola; Francis Ribeiro; Guilherme Fonseca; Heidi Dalton; Mehul Desai; Erik Osborn; Hala Deeb; Antonio Arcadipane; Gennaro Martucci; Giovanna Panarello; Chiara Vitiello; Claudia Bianco; Giovanna Occhipinti; Matteo Rossetti; Raffaele Cuffaro; Sung-Min Cho Johns; Hiroaki Shimizu; Naoki Moriyama; Jae-Burm Kim; Nobuya Kitamura; Alyaa Elhazmi; Abdullah Al-Hudaib; Johannes Gebauer; Toshiki Yokoyama; Abdulrahman Al-Fares; Sarah Buabbas; Esam Alamad; Fatma Alawadhi; Kalthoum Alawadi; Hiro Tanaka; Satoru Hashimoto; Masaki Yamazaki; Tak-Hyuck Oh; Mark Epler; Cathleen Forney; Louise Kruse; Jared Feister; Joelle Williamson; Katherine Grobengieser; Eric Gnall; Sasha Golden; Mara Caroline; Timothy Shapiro; Colleen Karaj; Lisa Thome; Lynn Sher; Mark Vanderland; Mary Welch; Sherry McDermott; Matthew Brain; Sarah Mineall; Dai Kimura; Luca Brazzi; Gabriele Sales; Tawnya Ogston; Dave Nagpal; Karlee Fischer; Roberto Lorusso; Mariano Esperatti; Edmund G. Carton; Ayan Sen; Amanda Palacios; Deborah Rainey; Gordan Samoukoviv; Josie Campisi; Emily Neumann; Cassandra Seefeldt; Lucia Durham; Octavio Falcucci; Amanda Emmrich; Jennifer Guy; Carling Johns; Nina Buchtele; Michael Schwameis; Stephanie-Susanne Stecher; Delila Singh; Michaela Barnikel; Lukas Arenz; Akram Zaaqoq; Lan Anh Galloway; Caitlin Merley; Marc Csete; Luisa Quesada; Isabela Saba; Daisuke Kasugai; Hiroaki Hiraiwa; Taku Tanaka; Eva Marwali; Yoel Purnama; Santi Rahayu Dewayanti; Ardiyan; Dafsah Arifa Juzar; Debby Siagian; Kita Jakarta; Yih-Sharng Chen; Mark Ogino; Indrek Ratsep; Getter Oigus; Kristo Erikson; Andra-Maris Post; Lauri Enneveer; Piret Sillaots; Frank Manetta; Effe Mihelis; Iam Claire Sarmiento; Mangala Narasimhan; Michael Varrone; Mamoru Komats; S. Veena Satyapriya; Amar Bhatt; Nahush A. Mokadam; Alberto Uribe; Alicia Gonzalez; Haixia Shi; Johnny McKeown; Joshua Pasek; Juan Fiorda; Marco Echeverria; Rita Moreno; Bishoy Zakhary; Marco Cavana; Alberto Cucino; Giuseppe Foti; Marco Giani; Vincenzo Russotto; Davide Chiumello; Valentina Castagna; Andrea Dell’Amore; Paolo Navalesi; Hoi-Ping Shum; Alain Vuysteke; Asad Usman; Andrew Acker; Benjamin Smood; Blake Mergler; Federico Sertic; Madhu Subramanian; Alexandra Sperry; Nicolas Rizer; Erlina Burhan; Menaldi Rasmin; Ernita Akmal; Faya Sitompul; Navy Lolong; Bhat Naivedh; Simon Erickson; Peter Barrett; David Dean; Julia Daugherty; Antonio Loforte; Irfan Khan; Mohammed Abraar Quraishi; Olivia DeSantis; Dominic So; Darshana Kandamby; Jose M. Mandei; Hans Natanael; Eka YudhaLantang; Anastasia Lantang; Surya Oto Wijaya; Anna Jung; George Ng; Wing Yiu Ng; Pauline Yeung Ng; Alexis Tabah; Megan Ratcliffe; Maree Duroux; Shingo Adachi; Shota Nakao; Pablo Blanco; Ana Prieto; Jesús Sánchez; Meghan Nicholson; Warwick Butt; Alyssa Serratore; Carmel Delzoppo; Pierre Janin; Elizabeth Yarad; Richard Totaro; Jennifer Coles; Bambang Pujo; Robert Balk; Andy Vissing; Esha Kapania; James Hays; Samuel Fox; Garrett Yantosh; Pavel Mishin; Saptadi Yuliarto; Kohar Hari Santoso; Susanthy Djajalaksana; Arie Zainul Fatoni; Masahiro Fukuda; Keibun Liu; Paolo Pelosi; Denise Battaglini; Diego Bastos; Sérgio Gaião; Jessica Buchner; Young-Jae Cho; Su Hwan Lee; Pranya Sakiyalak; Prompak Nitayavardhana; Tamara Seitz; Rakesh Arora; David Kent; Swapnil Parwar; Andrew Cheng; Jennene Miller; Shigeki Fujitani; Naoki Shimizu; Jai Madhok; Clark Owyang; Hergen Buscher; Claire Reynolds; Olavi Maasikas; Aleksan Beljantsev; Vladislav Mihnovits; Takako Akimoto; Mariko Aizawa; Kanako Horibe; Ryota Onodera; Carol Hodgson; Aidan Burrell; Meredith Young; Kiran Shekar; Niki McGuinness; Lacey Irvine; Brigid Flynn; Kazuhiro Sugiyama; Keiki Shimizu; Eddy Fan; Kathleen Exconde; Shingo Ichiba; Leslie Lussier; Gösta Lotz; Lars Maier; Esther Dreier; Neurinda Permata Kusumastuti; Colin McCloskey; Al-Awwab Dabaliz; Tarek B Elshazly; Josiah Smith; Konstanty S. Szuldrzynski; Piotr Bielański; Keith Wille; Srinivas Murthy; Ken Kuljit S. Parhar; Kirsten M. Fiest; Cassidy Codan; Anmol Shahid; Mohamed Fayed; Timothy Evans; Rebekah Garcia; Ashley Gutierrez; Tae Song; Rebecca Rose; Suzanne Bennett; Denise Richardson; Lovkesh Arora; Kristina Rappapport; Kristina Rudolph; Zita Sibenaller; Lori Stout; Alicia Walter; Daniel Herr; Nazli Vedadi; Robert Bartlett; Antonio Pesenti; Shaun Thompson; Lace Sindt; Sean Rajnic; Cale Ewald; Julie Hoffman; Matthew Griffee; Anna Ciullo; Yuri Kida; Ricard Ferrer Roca; JordI Riera; Sofia Contreras; Cynthia Alegre; Christy Kay; Irene Fischer; Elizabeth Renner; Hayato Taniguci; John Fraser; Gianluigi Li Bassi; Jacky Suen; Adrian Barnett; Nicole White; Kristen Gibbons; Simon Forsyth; Amanda Corley; India Pearse; Samuel Hinton; Gabriella Abbate; Halah Hassan; Silver Heinsar; Varun A Karnik; Katrina Ki; Hollier F. O’Neill; Nchafatso Obonyo; Janice D. Reid; Kei Sato; Aapeli Vuorinen; Karin S. Wildi; Emily S. Wood; Stephanie Yerkovich; James Lee; Daniel Plotkin; Laura Merson; Emma Hartley; Bastian Lubis; Takanari Ikeyama; Balu Bhaskar; Jae-Seung Jung; Shay McGuinness; Glenn Eastwood; Sandra Rossi Marta; Fabio Guarracino; Stacy Gerle; Emily Coxon; Bruno Claro; Gonzo Gonzalez-Stawinski; Daniel Loverde; Namrata Patil; Vieri Parrini; Angela McBride; Kathryn Negaard; Angela Ratsch; Ahmad Abdelaziz; Juan David Uribe; Adriano Peris; Mark Sanders; Dominic Emerson; Muhammad Kamal; Pedro Povoa; Roland Francis; Ali Cherif; Sunimol Joseph; Matteo Di Nardo; Micheal Heard; Kimberly Kyle; Ray A Blackwell; Michael Piagnerelli; Patrick Biston; Hye Won Jeong; Reanna Smith; Yogi Prawira; Giorgia Montrucchio; Nadeem Rahman; Vivek Kakar; Josefa Valenzuela Sarrazin; Arturo Huerta Garcia; Nahikari Salterain; Bart Meyns; Marsha Moreno; Rajat Walia; Amit Mehta; Annette Schweda; Moh Supriatna; Bhirowo Yudo; Cenk Kirakli; Melissa Williams; Kyung Hoon Kim; Alexandra Assad; Estefania Giraldo; Wojtek Karolak; Martin Balik; Elizabeth Pocock; Evan Gajkowski; Kanamoto Masafumi; Nicholas Barrett; Yoshihiro Takeyama; Sunghoon Park; Faizan Amin; Fina Meilyana Andriyani; Serhii Sudakevych; Magdalena Vera; Rodrigo Cornejo; Patrícia Schwarz; Ana Carolina Mardini; Ary Serpa Neto; Andrea Villoldo; Alexandre Siciliano Colafranceschi; Alejandro Ubeda; Juan Granjean; Lívia Maria Garcia Melro; Giovana Fioravante Romualdo; Diego Gaia; Helmgton Souza; Filomena Galas; Rafael Máñez Mendiluce; Alejandra Sosa; Ignacio Martinez; Hiroshi Kurosawa; Juan Salgado; Beate Hugi-Mayr; Eric Charbonneau; Vitor Salvatore Barzilai; Veronica Monteiro; Rodrigo Ribeiro de Souza; Michael Harper; Hiroyuki Suzuki; Celina Adams; Jorge Brieva; George Nyale; Faisal Saleem Eltatar; Jihan Fatani; Husam Baeissa; Ayman AL Masri; Ahmed Rabie; Mok Yee Hui; Masahiro Yamane; Hanna Jung; Ayorinde Mojisola; Margaret; Newell Nacpil; Katja Ruck; Rhonda Bakken; Claire Jara; Tim Felton; Lorenzo Berra; Bobby Shah; Arpan Chakraborty; Monika Cardona; Gerry Capatos; Bindu Akkanti; Abiodun Orija; Harsh Jain; Asami Ito; Brahim Housni; Sennen Low; Koji Iihara; Joselito Chavez; Kollengode Ramanathan; Gustavo Zabert; Krubin Naidoo; Ian Seppelt; Marlice VanDyk; Sarah MacDonald; Randy McGregor; Teka Siebenaler; Hannah Flynn; Julia Garcia-Diaz; Catherine Harmon; Kristi Lofton; Toshiyuki Aokage; Kazuaki Shigemitsu; Andrea Moscatelli; Giuseppe Fiorentino; Matthias Baumgaertel; Serge Eddy Mba; Jana Assy; Amelya Hutahaean; Holly Roush; Kay A Sichting; Francesco Alessandri; Debra Burns; Gavin Salt; Carl P. Garabedian; Jonathan Millar; Malcolm Sim; Adrian Mattke; Danny McAuley; Jawad Tadili; Tim Frenzel; Yaron Bar-Lavie; Aaron Blandino Ortiz; Jackie Stone; Antony Attokaran; Michael Farquharson; Brij Patel; Derek Gunning; Kenneth Baillie; Pia Watson; Kenji Tamai; Gede Ketut Sajinadiyasa; Dyah Kanyawati; Marcello Salgado; Assad Sassine; Scott McCaul; Bongjin Lee; Sang Min Lee; Arnon Afek; Yoshiaki Iwashita; Laveena Munshi; Bambang Pujo Semedi; Neurinda Permata; Kusumastuti; Jack Metiva; Nicole Van Belle; Daniel Marino; Ignacio Martin-Loeches; Lenny Ivatt; Chia Yew Woon; Hyun Mi Kang; Timothy Smith; Erskine James; Nawar Al-Rawas; Tomoyuki Endo; Yudai Iwasaki; Kenny Chan King-Chung; Vadim Gudzenko; Fabio Taccone; Fajar Perdhana; Yoan Lamarche; Joao Miguel Ribeiro; Nikola Bradic; Klaartje Van den Bossche; Oude Lansink; Gurmeet Singh; Gerdy Debeuckelaere; Henry T. Stelfox; Cassia Yi; Jennifer Elia; Shu Fang; Thomas Tribble; Shyam Shankar; Raj Padmanabhan; Bill Hallinan; Luca Paoletti; Yolanda Leyva; Tatuma Fykuda; Jenelle Badulak; Jillian Koch; Amy Hackman; Lisa Janowaik; Deb Hernandez; Jennifer Osofsky; Katia Donadello; Aizah Lawang; Josh Fine; Benjamin Davidson; Andres Oswaldo Razo Vazquez
Source
Critical Care Explorations, Vol 3, Iss 11, p e0567 (2021)
Subject
Language
English
ISSN
2639-8028
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Abstract
IMPORTANCE:. Factors associated with mortality in coronavirus disease 2019 patients on invasive mechanical ventilation are still not fully elucidated. OBJECTIVES:. To identify patient-level parameters, readily available at the bedside, associated with the risk of in-hospital mortality within 28 days from commencement of invasive mechanical ventilation or coronavirus disease 2019. DESIGN, SETTING, AND PARTICIPANTS:. Prospective observational cohort study by the global Coronavirus Disease 2019 Critical Care Consortium. Patients with laboratory-confirmed coronavirus disease 2019 requiring invasive mechanical ventilation from February 2, 2020, to May 15, 2021. MAIN OUTCOMES AND MEASURES:. Patient characteristics and clinical data were assessed upon ICU admission, the commencement of invasive mechanical ventilation and for 28 days thereafter. We primarily aimed to identify time-independent and time-dependent risk factors for 28-day invasive mechanical ventilation mortality. RESULTS:. One-thousand five-hundred eighty-seven patients were included in the survival analysis; 588 patients died in hospital within 28 days of commencing invasive mechanical ventilation (37%). Cox-regression analysis identified associations between the hazard of 28-day invasive mechanical ventilation mortality with age (hazard ratio, 1.26 per 10-yr increase in age; 95% CI, 1.16–1.37; p < 0.001), positive end-expiratory pressure upon commencement of invasive mechanical ventilation (hazard ratio, 0.81 per 5 cm H2O increase; 95% CI, 0.67–0.97; p = 0.02). Time-dependent parameters associated with 28-day invasive mechanical ventilation mortality were serum creatinine (hazard ratio, 1.28 per doubling; 95% CI, 1.15–1.41; p < 0.001), lactate (hazard ratio, 1.22 per doubling; 95% CI, 1.11–1.34; p < 0.001), Paco2 (hazard ratio, 1.63 per doubling; 95% CI, 1.19–2.25; p < 0.001), pH (hazard ratio, 0.89 per 0.1 increase; 95% CI, 0.8–14; p = 0.041), Pao2/Fio2 (hazard ratio, 0.58 per doubling; 95% CI, 0.52–0.66; p < 0.001), and mean arterial pressure (hazard ratio, 0.92 per 10 mm Hg increase; 95% CI, 0.88–0.97; p = 0.003). CONCLUSIONS AND RELEVANCE:. This international study suggests that in patients with coronavirus disease 2019 on invasive mechanical ventilation, older age and clinically relevant variables monitored at baseline or sequentially during the course of invasive mechanical ventilation are associated with 28-day invasive mechanical ventilation mortality hazard. Further investigation is warranted to validate any causative roles these parameters might play in influencing clinical outcomes.