학술논문
Impact of uncertainties in exposure assessment on estimates of thyroid cancer risk among Ukrainian children and adolescents exposed from the Chernobyl accident.
Document Type
article
Author
Mark P Little; Alexander G Kukush; Sergii V Masiuk; Sergiy Shklyar; Raymond J Carroll; Jay H Lubin; Deukwoo Kwon; Alina V Brenner; Mykola D Tronko; Kiyohiko Mabuchi; Tetiana I Bogdanova; Maureen Hatch; Lydia B Zablotska; Valeriy P Tereshchenko; Evgenia Ostroumova; André C Bouville; Vladimir Drozdovitch; Mykola I Chepurny; Lina N Kovgan; Steven L Simon; Victor M Shpak; Ilya A Likhtarev
Source
PLoS ONE, Vol 9, Iss 1, p e85723 (2014)
Subject
Language
English
ISSN
1932-6203
Abstract
The 1986 accident at the Chernobyl nuclear power plant remains the most serious nuclear accident in history, and excess thyroid cancers, particularly among those exposed to releases of iodine-131 remain the best-documented sequelae. Failure to take dose-measurement error into account can lead to bias in assessments of dose-response slope. Although risks in the Ukrainian-US thyroid screening study have been previously evaluated, errors in dose assessments have not been addressed hitherto. Dose-response patterns were examined in a thyroid screening prevalence cohort of 13,127 persons aged