학술논문
Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration
Document Type
article
Author
Eric E. Smith; Geert Jan Biessels; François De Guio; Frank Erik deLeeuw; Simon Duchesne; Marco Düring; Richard Frayne; M. Arfan Ikram; Eric Jouvent; Bradley J. MacIntosh; Michael J. Thrippleton; Meike W. Vernooij; Hieab Adams; Walter H. Backes; Lucia Ballerini; Sandra E. Black; Christopher Chen; Rod Corriveau; Charles DeCarli; Steven M. Greenberg; M. Edip Gurol; Michael Ingrisch; Dominic Job; Bonnie Y.K. Lam; Lenore J. Launer; Jennifer Linn; Cheryl R. McCreary; Vincent C.T. Mok; Leonardo Pantoni; G. Bruce Pike; Joel Ramirez; Yael D. Reijmer; Jose Rafael Romero; Stefan Ropele; Natalia S. Rost; Perminder S. Sachdev; Christopher J.M. Scott; Sudha Seshadri; Mukul Sharma; Steven Sourbron; Rebecca M.E. Steketee; Richard H. Swartz; Robert vanOostenbrugge; Matthias vanOsch; Sanneke vanRooden; Anand Viswanathan; David Werring; Martin Dichgans; Joanna M. Wardlaw
Source
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 191-204 (2019)
Subject
Language
English
ISSN
2352-8729
53376730
53376730
Abstract
Abstract Introduction Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease. Methods Surveys, teleconferences, and an in‐person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis. Results A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness‐neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository. Conclusions The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.