학술논문
A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood
Document Type
article
Author
Nuzulul Kurniansyah; Matthew O. Goodman; Tanika N. Kelly; Tali Elfassy; Kerri L. Wiggins; Joshua C. Bis; Xiuqing Guo; Walter Palmas; Kent D. Taylor; Henry J. Lin; Jeffrey Haessler; Yan Gao; Daichi Shimbo; Jennifer A. Smith; Bing Yu; Elena V. Feofanova; Roelof A. J. Smit; Zhe Wang; Shih-Jen Hwang; Simin Liu; Sylvia Wassertheil-Smoller; JoAnn E. Manson; Donald M. Lloyd-Jones; Stephen S. Rich; Ruth J. F. Loos; Susan Redline; Adolfo Correa; Charles Kooperberg; Myriam Fornage; Robert C. Kaplan; Bruce M. Psaty; Jerome I. Rotter; Donna K. Arnett; Alanna C. Morrison; Nora Franceschini; Daniel Levy; the NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium; Tamar Sofer
Source
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Polygenic risk scores have potential to predict an individual’s risk of disease based on genetic markers. Here, the authors develop a polygenic risk score for hypertension and test it in a multi-ethnic cohort, finding that the score is associated with higher likelihood of hypertension development 4-6 years later.