학술논문
Low pre-ART CD4 count is associated with increased risk of clinical progression or death even after reaching 500 CD4 cells/μL on ART.
Document Type
article
Author
Nikos Pantazis; Vasilios Paparizos; Vasilios Papastamopoulos; Simeon Metallidis; Anastasia Antoniadou; Georgios Adamis; Mina Psichgiou; Maria Chini; Helen Sambatakou; Georgios Chrysos; Nikolaos V Sipsas; Charalambos Gogos; Emmanouil Barbunakis; Periklis Panagopoulos; Olga Katsarou; Giota Touloumi; Athens Multicenter AIDS Cohort Study (AMACS)
Source
PLoS ONE, Vol 18, Iss 3, p e0283648 (2023)
Subject
Language
English
ISSN
1932-6203
Abstract
IntroductionClinical disadvantages of initiating ART at low CD4 counts have been clearly demonstrated but whether any excess risk remains even after reaching relatively high/safe CD4 levels remains unclear. We explore whether individuals starting ART with MethodsData were derived from a multicenter cohort (AMACS). Adults, starting PI, NNRTI or INSTI based ART, in or after 2000 were eligible, provided they started ART with ≥500 ("High CD4") or started with CD4 ResultsThe study included 694 persons in the "High CD4" and 3,306 in the "Low CD4" group. Median (IQR) follow-up was 66 (36, 106) months. In total, 257 events (40 AIDS related, 217 SNAEs) were observed. Rates of progression did not differ significantly between the two groups but the subgroup of those initiating ART with ConclusionsIndividuals starting ART with