학술논문
Severe COVID-19 patients have impaired plasmacytoid dendritic cell-mediated control of SARS-CoV-2
Document Type
article
Author
Source
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Plasmacytoid DC (pDC) have been shown to secrete type I IFN and to be involved in controlling replication and spread of some viruses. Here the authors show that in severe SARS-CoV-2 infection pDC function is impaired leading to reduced type I IFN production and possibly lower viral control.