학술논문

In silico reproduction of the pathophysiology of in-stent restenosis
Document Type
Working Paper
Source
Subject
Physics - Biological Physics
Physics - Fluid Dynamics
Language
Abstract
The occurrence of in-stent restenosis following percutaneous coronary intervention highlights the need for the creation of computational tools that can extract pathophysiological insights and optimize interventional procedures on a patient-specific basis. In light of this, a comprehensive framework encompassing multiple physical phenomena is introduced in this work. This framework effectively captures the intricate interplay of chemical, mechanical, and biological factors. In addition, computational approaches for the extraction of hemodynamic indicators that modulate the severity of the restenotic process are devised. Thus, this marks a significant stride towards facilitating computer-assisted clinical methodologies.
Comment: 17 pages, 12 figures Revision in section 2.3: added Table 1, correted signs in Table 2, added 2 references and some details. Revision in section 3.3: restructured order of figures