부산대학교 도서관

Proton arc therapy has emerged as a promising approach for faster treatment delivery in comparison to conventional proton treatments. However, unexpected prolonged treatment times in several proton arc planning studies have raised concerns. In this study, we aim to address the challenge of minimizing delivery time through dosimetry-guided energy layer filtering, comparing its performance to a baseline approach without filtering. We developed three methods of energy layer (EL) filtering: unrestricted, switch-up (SU), and switch-up gap (SU gap) filtering. The unrestricted method filters the lowest weighted EL while the SU gap filtering removes in priority the EL around a new SU to minimize the gantry rotation braking. The SU filtering removes the lowest weighted group of EL that includes a SU. These post-processing filters were used in conjunction with the RayStation dynamic proton arc optimization framework (ELSA). Four bilateral oropharyngeal cancer patients' data were used for evaluation. Objective function values, target coverage robustness, organ-at-risk doses and NTCP evaluations, as well as comparisons to IMPT plans, were used to assess plan quality. The SU gap filtering algorithm performed best in three out of the four cases, maintaining plan quality within tolerance while significantly reducing beam delivery time. It achieved up to approximately 22% reduction in delivery time. The unrestricted filtering algorithm followed closely. In contrast, the SU filtering showed limited improvement, suppressing hardly a few SU without substantial delivery time shortening. Robust target coverage was kept within 1% of variation compared to the ELSA baseline plan while OAR doses slighlty decreased in all four patients. Both arc plans present large reductions in NTCP values for dysphagia and xerostomia compared to the reference IMPT plan.
Comment: 14 pages, 8 figures, submitted to Physics in Medicine and Biology