학술논문
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation
Document Type
Article
Author
Source
In Cell Chemical Biology 17 October 2024 31(10):1772-1786
Subject
Language
ISSN
2451-9456
Abstract
@@@@Although suppression of liver glucose production reduces hyperglycemia in diabetes, this inhibition can promote de novo lipogenesis from gluconeogenic substrates, exacerbating hepatic steatosis and compromising clinical interventions. Mutlu et al. elucidate how the small molecule SR18292 represses hepatic gluconeogenesis without perturbation of lipogenesis.