학술논문
The role of gut microbiota in prostate inflammation and benign prostatic hyperplasia and its therapeutic implications
Document Type
Review Article
Author
Chen, Jie ; Chen, Bo ; Lin, Bin ; Huang, Yin ; Li, Jinze ; Li, Jin ; Chen, Zeyu ; Wang, Puze ; Ran, Biao ; Yang, Jiahao ; Huang, Huijian ; Liu, Liangren ; Wei, Qiang ; Ai, Jianzhong ; Cao, Dehong
Source
In Heliyon 15 October 2024 10(19)
Subject
Language
ISSN
2405-8440
Abstract
Conclusion Short-chain fatty acids (SCFAs), which are metabolites of the intestinal microbiota, protect the integrity of the intestinal barrier, regulate immunity, and inhibit inflammation. However, dysregulation of the gut microbiota significantly reduces the SCFA content in feces and impairs the integrity of the gut barrier, leading to the translocation of bacteria and bacterial components such as lipopolysaccharide, mediating the development of prostate inflammation through microbe-associated molecular patterns (MAMPs).