학술논문
Methionine restriction alleviates diabetes-associated cognitive impairment via activation of FGF21
Document Type
Article
Author
Zhang, Yuyu ; Wang, Yajie ; Li, Yiju ; Pang, Jingxi ; Höhn, Annika ; Dong, Weixuan ; Gao, Rui ; Liu, Yan ; Wang, Da ; She, Yongbo ; Guo, Rui ; Liu, Zhigang
Source
In Redox Biology November 2024 77
Subject
Language
ISSN
2213-2317
Abstract
Highlights •Methionine restriction (MR) improves peripheral insulin sensitivity in T2DM mice.•MR activates ATF4/PPARα and enhances hepatic FGF21 generation in T2DM mice.•MR alleviates cognitive impairment and boosts brain glucose uptake in T2DM mice.•MR balances redox homeostasis and neuroinflammation in the brain of T2DM mice.•FGFR1 is essential for regulating brain glucose uptake in response to MR.