학술논문
TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction
Document Type
Article
Author
Zhang, Xiaoxue ; Shao, Jichen ; Wang, Caixue ; Liu, Chao ; Hao, Han ; Li, Xinmeng ; An, Yating ; He, Jinsha ; Zhao, Weixin ; Zhao, Yiwen ; Kong, Youzhen ; Jia, Zhanfeng ; Wan, Shaopo ; Yuan, Yi ; Zhang, Huiran ; Zhang, Hailin ; Du, Xiaona
Source
In Cell Reports 23 April 2024 43(4)
Subject
Language
ISSN
2211-1247
Abstract
@@@@Zhang et al. report that TMC7 is co-expressed with Piezo2 in somatosensory neurons. TMC7 functions as a suppressor of Piezo2 through direct interaction with the channel. Deletion of TMC7 enhances physiological and pathological sensory mechanotransduction, suggesting that TMC7 could serve as a potential therapeutic target for alleviating pathological pain.