학술논문
The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development
Document Type
Article
Author
Source
In Cell Reports 26 March 2024 43(3)
Subject
Language
ISSN
2211-1247
Abstract
@@@@Wang et al. report that Tet2/3 proteins are essential for craniofacial cartilage development, regulating chondrocyte differentiation through BMP signaling. Sall4 directs the co-phase separation of Tet2/3 with Sall4 to form condensates that mediate 5mC oxidation on the bmp4 promoter, promoting bmp4 expression and craniofacial cartilage formation.