학술논문
Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders
Document Type
Article
Author
Source
In Cell Reports 27 June 2023 42(6)
Subject
Language
ISSN
2211-1247
Abstract
Gao et al. identify the existence of two distinct phenotypes of microglia and infiltrating myeloid cells dependent on TREM2 expression levels at the acute stage of spinal cord injury (SCI) and experimental autoimmune encephalomyelitis (EAE), and the authors elucidate how they mediate the opposing effects of TREM2 in the two disorder models.