학술논문
The history of mutational pressure changes during the evolution of adeno-associated viruses: A message to gene therapy and DNA-vaccine vectors designers
Document Type
Article
Author
Source
In Infection, Genetics and Evolution January 2020 77
Subject
Language
ISSN
1567-1348
Abstract
Highlights •Mutational pressure direction should be considered during DNA vector design•Effects of mutational pressure should be distinguished from translational selection•AAV of different types demonstrate different mutational pressure directions•The rate of transcription influences the direction of mutational pressure in AAV•ORF2 of the common predecessor of human AAV, except AAV5, suffered from AT-pressure