학술논문
A nanozyme-based drug delivery system to amplify ferroptosis via MET inhibition and photodynamic therapy
Document Type
Article
Author
Xu, Mengran ; Lai, Fuxuan ; Liu, Hu ; Hu, Delin ; Sun, Yexiang ; Li, Fenfen ; Sun, Min ; Lv, Na ; Qiu, Bensheng ; Pan, Yueyin ; Hu, Yi
Source
In Chemical Engineering Journal 15 November 2024 500
Subject
Language
ISSN
1385-8947
Abstract
Highlights •The GSH oxidase-like activity of MIL-53 depletes GSH, overcoming ferroptosis resistance in tumors.•The catalase-like activity of MIL-53 boosts photodynamic therapy by generating oxygen through the decomposition of H2O2.•The photodynamic effect of MMSC generates singlet oxygen, further amplifying ferroptosis.•cMBP peptide modification attenuates MET pathway in MET-overexpressing tumors, reducing antioxidant capacity and promoting ferroptosis.•Transcriptomic analysis revealed that MMSC modulates the expression of ferroptosis-related and MET signaling pathways-related genes.