학술논문
The novel DNA methylation marker FIBIN suppresses non-small cell lung cancer metastasis by negatively regulating ANXA2
Document Type
Article
Author
Peng, Mingyu ; Yang, Li ; Liao, Jiaxin ; Le, Xin ; Dai, Fengsheng ; Sun, Ran ; Wu, Fan ; Jiang, Yu ; Tian, Rui ; Shao, Bianfei ; Zhou, Li ; Wu, Mingjun ; Guo, Shuliang ; Xiang, Tingxiu
Source
In Cellular Signalling August 2024 120
Subject
Language
ISSN
0898-6568
Abstract
@@@@Highlights •FIBIN is significantly downregulated in lung cancer.•Downregulation of FIBIN is associated with hypermethylation of its promoter in lung cancer.•FIBIN exerts a tumor suppressor effect in lung cancer, especially in metastasis.•FIBIN regulating ANXA2 expression levels, subcellular localization, and protein stability.•FIBIN suppress metastasis via ANXA2/ GSK-3β/ β-catenin axis.