학술논문
TNFR2 signaling in oligodendrocyte precursor cells suppresses their immune-inflammatory function and detrimental microglia activation in CNS demyelinating disease
Document Type
Article
Author
Source
In Brain Behavior and Immunity January 2025 123:81-98
Subject
Language
ISSN
0889-1591
Abstract
Highlights •Combining in vivo and in vitro studies, we show that TNFR2 signaling in OPCs is protective in CNS demyelinating disease.•TNFR2 signaling in OPCs suppresses the inflammatory function of OPCs and prevents neurotoxic microglial activation.