학술논문
Oleanolic acid 28-O-β-D-glucopyranoside: A novel therapeutic agent against ulcerative colitis via anti-inflammatory, barrier-preservation, and gut microbiota-modulation
Document Type
Article
Author
Source
In Biomedicine & Pharmacotherapy November 2024 180
Subject
Language
ISSN
0753-3322
Abstract
@@@@Highlights •OAG exerts anti-inflammatory and barrier-protective effects in LPS-induced Caco-2 cells.•OAG alleviates UC symptoms and reduces inflammation in DSS-induced UC mice.•OAG enhances intestinal barrier function, outperforming 5-aminosalicylic acid.•OAG rebalances gut microbiome by promoting beneficial and reducing harmful bacteria.•PI3K-AKT and MAPK pathways are crucial for OAG's therapeutic effects on UC.