학술논문
Polymer chain extenders induce significant toxicity through DAF-16 and SKN-1 pathways in Caenorhabditis elegans: A comparative analysis
Document Type
Article
Author
Mo, Aoyun ; Liang, Yuqing ; Cao, Xiaomu ; Jiang, Jie ; Liu, Yan ; Cao, Xuelong ; Qiu, Yuping ; He, Defu
Source
In Journal of Hazardous Materials 15 July 2024 473
Subject
Language
ISSN
0304-3894
Abstract
Highlights •Ecotoxicity of ten common chain extenders was comparatively investigated using C. elegans.•LC50 of chain extenders varied from 92.42 µg L−1 to 1553.65 mg L−1 after acute exposure.•Sublethal exposures induced various toxicity on growth, lifespan, neurons, and reproductive.•Chain extenders caused upregulated expression of ctl-1,2,3, sod-3, gcs-1, and gst-4.•Hexamethylene diisocyanate/diallyl maleate exhibited high toxicity by comparative analysis.