학술논문
From lab to clinic: The discovery and optimization journey of PI3K inhibitors
Document Type
Article
Author
Lian, Siyu ; Du, Zhenhua ; Chen, Qingqing ; Xia, Yu ; Miao, Xinxin ; Yu, Weiwei ; Sun, Qian ; Feng, Chong
Source
In European Journal of Medicinal Chemistry 5 November 2024 277
Subject
Language
ISSN
0223-5234
Abstract
@@@@Highlights •The discovery and optimization journey of PI3K inhibitors from lab to the clinic is timely organized.•Key design principles of representative PI3K Inhibitors in the clinic are emphasized.•Challenges and opportunities are briefly discussed to facilitate the development of novel PI3K inhibitors.